Williamson Medical Center is operated by the citizens of Williamson County through its Board of Trustees. The Medical Center Board of Trustees is made up of individuals from the Williamson County community. The Board includes civic leaders, private citizens, government leaders and physicians.

The following individuals comprise the Williamson Medical Center Board of Trustees.

• Rogers Anderson, County Executive
• A.J. Bethurum, M.D. 
• Isaac (Ike) Brown, Trustee Emeritus
• James "Bo" Butler
• Bertram (Bert) Chalfant
• James W. (Jim) Cross, IV
• Brown Daniel
• M. Craig Ferrell, M.D.
• Russell Little, Chairman
• Clyde Lynch
• Mary Mills
• Kathy McGee, R.N.